I have been asked to comment on the following case:
Do you need to know LDL particle size (large or small, dense) in order to dx with certainty FH vs. FCHL? What about a 62 yr. old woman without any hx. of HTN, DM 2, CHD or its equivalent, with a lipid profile as follows: TC: 375 Trigs: 239 HDL: 52 LDL: 277. Glu: 100. No waist >35" Family hx. negative for premature CAD, but positive for high cholesterol. No siblings or children. She has no xanthomas/xanthelasmas.
The providers first impression was FH mixed with secondary dyslipidemic features. He is going to do a Lipoprotein NMR anyway, but wants to know can you already make the dx of FH?
For my answer - Click on the groups page URL above Click on the Dayspring Groups and then click on Lipid Geeks