Does anyone have significant clinical experience with genetic testing for FH with LDL-R or ApoB mutation assays. Several labs offer these DNA studies for definitive diagnosis. It is tantalizing to be certain, but the cost ($1500+) is significant. Also other assays for ApoA2, PON2, ApoC3, ABCA1 etc are available from some labs as a "comprehensive screen for familial early atherosclerosis." I'd be interested in your non-research justification, if any, for these tests.
