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Lipidaholics: Time to learn about LDL-TG values. Please click on the groups tab above and go to Dayspring Lipidaholics Anonymous Group - Read the newest case.  Join the group and post comments on the case.  Happy Lipiding,  TD

Keywords: ldl-p 

Lipidaholics: Case # 245 has been posted at my Lipidaholics Group site. Click on groups above, go to Dayspring and then Lipidaholics Group and see how you stack up in estimating CHD risk inb a 50 year old woman. Ad your comments.

 

TD

Keywords: ldl-p women ldl-p 

There is a new posting at my Lipid Geeks group: read the case and see if you would prescribe a statin or not to a patient with a normal LDL-P. Please feel free to post comments.

Keywords: ldl-p women ldl-p triglycerides ldl-p apob 

Go over to the Groups Section and click on Lipidaholics and check out the new  case discussion which illustrates some very important concepts, specifically understanding the core composition of LDL particles.

Keywords: ldl-p women ldl-p triglycerides ldl-p apob lipoproteins triglycerides ldl-p apob 

Interesting case discussion where a rising LDL-C in a diabetic is of no concern. Go over to the Lipdaholics Groups page to see the case and add comments

Keywords: ldl-p women ldl-p triglycerides ldl-p apob lipoproteins triglycerides ldl-p apob ldl-p diabetes 

Please go over to the Lipid Geeks group under Groups URL and see my comments on a very inetersting case entitled "A case report of a diabetic woman with very low HDL-C."  You will learn something about HDL mapping but you will not miss the forest through the trees.

 

Tom D

Keywords: ldl-p women ldl-p triglycerides ldl-p apob lipoproteins triglycerides ldl-p apob ldl-p diabetes hdl-c ldl-p diabetes 

The following article written by myself and Tara Dall is available for free and can be downloaded. It is called: "MOVING beyond LDL-C incorporating lipoprotein particle numbers and geometric parameters to improve clinical outcomes"

 

 http://www.dovepress.com/article_5601.t2554196

 

Abstract: Lipoproteins are complex protein-enwrapped particles which traffic hydrophobic lipids and other molecules between tissues in plasma. Under a variety of pathological states, specific lipoproteins trafficking sterols, phospholipids, and fatty acids enter arterial walls enhancing a maladaptive inflammatory response resulting in atherogenesis. Several lipoprotein particle geometric parameters are now readily available from the laboratory. Such measurements beyond standard lipid concentrations can be used to better understand both the link between atherogenesis and the trafficking patterns of lipoproteins. Often, the various laboratory indices, especially standard particle lipid concentrations versus lipoprotein particle parameters, seem to conflict or exhibit discordance and thus confuse the patient and the provider. By using readily available (but often misunderstood) particle geometric parameters from two patients, we have attempted to illustrate that by properly utilizing the newer assays, very discordant standard lipid concentrations and lipoprotein laboratory parameters can be present in two specific patients and demonstrate how the newer parameters can aid the clinicians in performing better risk assessment and treatment decisions.

Keywords: ldl-p women ldl-p triglycerides ldl-p apob lipoproteins triglycerides ldl-p apob ldl-p diabetes hdl-c ldl-p diabetes ldl ldl-p ldl-c size compostiion 

For a thorough discussion of how critically important lipoprotein compostion is in impacting apoB and LDL-P. This is the critical pathophysiology not being taught! Did you know LDL-TG outpredicts LDL-C as a risk factor?  Why? Here is the study no one has ever read.  The Ludwigshafen Risk and Cardiovascular Health Study.  Conclusions: Alterations of LDL metabolism characterized by high LDL-TG are related to CAD, systemic low-grade inflammation, and vascular damage. High LDL-TGs are indicative of CE-depleted LDL, elevated IDL, and dense LDL. LDL-TG may better reflect the atherogenic potential of LDL than LDL-C. (Circulation. 2004;110:3068-3074.)   Go over to my Lipid Geeks group and learn why particle compositon not particle size rules! For slides accompanying slides go to my web site www.lipidcenter.com  click on professionals, click on lipid and lipoprotein study materials and then click on Lipoprotein anatomy

Keywords: ldl-p women ldl-p triglycerides ldl-p apob lipoproteins triglycerides ldl-p apob ldl-p diabetes hdl-c ldl-p diabetes ldl ldl-p ldl-c size compostiion ldl-p apob. ldl-tg lipoproteins 

Please go over to my groups page and click on Lipidaholics Anonymous to see a case discussion where a lipidologist and his nurese practitioner analyzed the same case - see who suggested what and then read my comments as I analyzed their statements.

 

TD

Keywords: ldl-p women ldl-p triglycerides ldl-p apob lipoproteins triglycerides ldl-p apob ldl-p diabetes hdl-c ldl-p diabetes ldl ldl-p ldl-c size compostiion ldl-p apob. ldl-tg lipoproteins ldl-p triglycerides 

Venture over to my Lipidaholics group for another pretty deep discussion on the importance of TG-rich lipoproteins. Tragically the discussion was stimuated by a frustrated PhRMA rep trying to deal with a cardiologist who cannot justify drug therapy for elevated triglycerides. As usual I take no prisoners!

 

Tom D

Keywords: ldl-p women ldl-p triglycerides ldl-p apob lipoproteins triglycerides ldl-p apob ldl-p diabetes hdl-c ldl-p diabetes ldl ldl-p ldl-c size compostiion ldl-p apob. ldl-tg lipoproteins ldl-p triglycerides triglycerides apob ldl-p hdl-p vldl insulin resistance 

Go over to my Lipidaholics Group page and get into the case which asks does a seemingly healthy 38 year old woman with an extremely low Framingham Risk Score need advanced CV tresting?  Post you comments please!  Do you all know who was Rachel Jackson?  This case is dedicated to her.

Keywords: ldl-p women ldl-p triglycerides ldl-p apob lipoproteins triglycerides ldl-p apob ldl-p diabetes hdl-c ldl-p diabetes ldl ldl-p ldl-c size compostiion ldl-p apob. ldl-tg lipoproteins ldl-p triglycerides triglycerides apob ldl-p hdl-p vldl insulin resistance ldl-p apob. lipoproteins risk advanced testing