
Lipidaholics: Case # 245 has been posted at my Lipidaholics Group site. Click on groups above, go to Dayspring and then Lipidaholics Group and see how you stack up in estimating CHD risk inb a 50 year old woman. Ad your comments.
TD
There is a new posting at my Lipid Geeks group: read the case and see if you would prescribe a statin or not to a patient with a normal LDL-P. Please feel free to post comments.
Please go over to the Lipid Geeks group under Groups URL and see my comments on a very inetersting case entitled "A case report of a diabetic woman with very low HDL-C." You will learn something about HDL mapping but you will not miss the forest through the trees.
Tom D
The following article written by myself and Tara Dall is available for free and can be downloaded. It is called: "MOVING beyond LDL-C incorporating lipoprotein particle numbers and geometric parameters to improve clinical outcomes"
http://www.dovepress.com/article_5601.t2554196
Abstract: Lipoproteins are complex protein-enwrapped particles which traffic hydrophobic lipids and other molecules between tissues in plasma. Under a variety of pathological states, specific lipoproteins trafficking sterols, phospholipids, and fatty acids enter arterial walls enhancing a maladaptive inflammatory response resulting in atherogenesis. Several lipoprotein particle geometric parameters are now readily available from the laboratory. Such measurements beyond standard lipid concentrations can be used to better understand both the link between atherogenesis and the trafficking patterns of lipoproteins. Often, the various laboratory indices, especially standard particle lipid concentrations versus lipoprotein particle parameters, seem to conflict or exhibit discordance and thus confuse the patient and the provider. By using readily available (but often misunderstood) particle geometric parameters from two patients, we have attempted to illustrate that by properly utilizing the newer assays, very discordant standard lipid concentrations and lipoprotein laboratory parameters can be present in two specific patients and demonstrate how the newer parameters can aid the clinicians in performing better risk assessment and treatment decisions.
Please go over to my groups page and click on Lipidaholics Anonymous to see a case discussion where a lipidologist and his nurese practitioner analyzed the same case - see who suggested what and then read my comments as I analyzed their statements.
TD
Venture over to my Lipidaholics group for another pretty deep discussion on the importance of TG-rich lipoproteins. Tragically the discussion was stimuated by a frustrated PhRMA rep trying to deal with a cardiologist who cannot justify drug therapy for elevated triglycerides. As usual I take no prisoners!
Tom D