Sep 2, 2009
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I have been asked to comment on the following case:
Do you need to know LDL particle size (large or small, dense) in order to dx with certainty FH vs. FCHL? What about a 62 yr. old woman without any hx. of HTN, DM 2, CHD or its equivalent, with a lipid profile as follows: TC: 375 Trigs: 239 HDL: 52 LDL: 277. Glu: 100. No waist >35" Family hx. negative for premature CAD, but positive for high cholesterol. No siblings or children. She has no xanthomas/xanthelasmas.
The providers first impression was FH mixed with secondary dyslipidemic features. He is going to do a Lipoprotein NMR anyway, but wants to know can you already make the dx of FH?
For my answer - Click on the groups page URL above Click on the Dayspring Groups and then click on Lipid Geeks
Jan 4, 2010
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The most recent Lipidaholics Anonymous Case has been posted under Groups: Lipidaholics. I pose the following question: Please surprise me with the correct answer: Who said and when did they say: "In a desire to use more specific terminology, certain durable nouns from the lipid era should not be discarded." The nouns being referred to are hypercholesterolemia and hypertriglyceridemia. Next question - if that is true, when did the lipid era end and what followed it? Third and final question: how many practicing physicians and lipidologists even know the lipid era has ended?
For the answer you have to read the case - Trust me you will be rewarded and perhaps very surprised.
Happy New Year, Tom Dayspring
Feb 26, 2010
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Go over to the Groups Section and click on Lipidaholics and check out the new case discussion which illustrates some very important concepts, specifically understanding the core composition of LDL particles.
Jul 5, 2010
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For a thorough discussion of how critically important lipoprotein compostion is in impacting apoB and LDL-P. This is the critical pathophysiology not being taught! Did you know LDL-TG outpredicts LDL-C as a risk factor? Why? Here is the study no one has ever read. The Ludwigshafen Risk and Cardiovascular Health Study. Conclusions: Alterations of LDL metabolism characterized by high LDL-TG are related to CAD, systemic low-grade inflammation, and vascular damage. High LDL-TGs are indicative of CE-depleted LDL, elevated IDL, and dense LDL. LDL-TG may better reflect the atherogenic potential of LDL than LDL-C. (Circulation. 2004;110:3068-3074.) Go over to my Lipid Geeks group and learn why particle compositon not particle size rules! For slides accompanying slides go to my web site
www.lipidcenter.com click on professionals, click on lipid and lipoprotein study materials and then click on Lipoprotein anatomy
Keywords: lipoproteins
ldl-p (7)
