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CLM-SAP 18: Translational Science of the LDL Receptor

This SAP is offered as part of the NLA's Translational Science of the LDL-Receptor Core Curriculum Intensive Program, which provides a comprehensive, in-depth indoctrination to advanced lipid science. The program is designed to address knowledge, competence, and practice gaps in managing residual CVD risk related to high LDL-C, and to provide lipid specialists with improved proficiency on the functionality and clinical implications of the LDL-Receptor and the complexities of LDL metabolism and targets of therapy.

The activity offers up to 3.25 CME/CE credit hours and contains board exam-style questions with corresponding educational critiques and references.

Utilizing the medical specialty board technology for examination development, scoring, analyses, and reporting, this activity consists of the following components:

The Assessment Component
The assessment component includes 61 clinical problem-solving multiple choice questions, which will objectively validate the most relevant clinical knowledge and assess your ability to accurately diagnose and manage patients with elevated LDL-C.

Educational Critiques Component
The educational critique component contains detailed explanations for all answers (correct and incorrect) that will immediately help you 1) to strengthen the weak areas identified in the confidential score results and 2) to reinforce positive areas of knowledge and understanding.

Accreditation Information

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Content Domain
This activity falls under the following content domain(s):

  • 1.1 Lipoprotein Composition and Structure

Learning Objectives
This activity teaches to the following learning objective(s):

  1. Describe genomic technology and the science of screening for mutations and genes that cause FH
  2. Describe the role of proprotein convertase subtilisin/kexin type 9 in lipoprotein metabolism including the LDL receptor and other receptor interactions
  3. Discuss the history of discovery of the LDL receptor
  4. Discuss the updated knowledge of Lp(a) metabolism, including production and clearance
  5. Interpret complex case reviews including differential diagnosis of LDLr disorders
  6. Outline factors having an impact on cardiovascular risk in patients with LDL disorders
  7. Outline the LDL receptors, metabolic pathways, and their pleiotropic effects



by Dr. Radut.