2011 NLA Scientific Sessions Highlights
Clinical Trial Updates Impacting Your Practice
What Do Simple Genetics Tell Us About Complex Diseases?
The Impact of Prescription Switching on LDL-C Goal Attainment
JoAnne M. Foody, MD, FACC, FAHA
Dr Foody focused on the unintended consequences of formulary changes and the potentially harmful effects, with respect to providing evidence-based care or meeting therapeutic goals. She noted that in the United Kingdom (UK), forced switching of high-dose to low-dose statin resulted in higher rates of death, cardiac death, and non-cardiac death in individuals switched to the lower dose.
Common Etiologies of Hypertriglyceridemia
Henry N. Ginsberg, MD
At least 95% of people with type-2 diabetes are insulin resistant. In the adipose tissue, insulin-resistant cells release fatty acids, increasing fatty acid flux to the liver resulting in transformation of the excess into triglycerides (TG)
Genetic Susceptibility to Statin-Induced Myopathy
Georgirene D. Vladutiu, PhD
Severe statin myopathy is usually defined as severe muscle damage with damage to another organ, such as a kidney, and creatinine kinase (CK) ≥10 x upper limit of normal (ULN). However, some severely affected patients have serum CK <10 x ULN. Of 166 patients with severe statin myopathy referred to Dr Vladutiu's laboratory, 40% had CK ≥10 x ULN, 30% had CK 4-9 x ULN, and 10-15% had CK 2-3 x ULN.