Introduction
Disclosure of Financial Relationships
Objectives
Outline
50 Things Guys Should Know About Pregnancy
Pregnancy & FH
Pregnancy Rates by Age
Main Changes in Lipoprotein Metabolism
Levels of TC, TGs, HDL, and LDL 1
LDL Cholesterol Levels in 5 pregnant women
LDL-C Levels During Pregancy in Women
Potential Issues/Concerns
FH Pregnancy Recommendations
FH Pregnancy Recommendations
NLA Recommendations 2011
Treatment Options During Pregnancy
Integrated FH Guidelines
Recommendations from International FH Foundation
Contraception
LDL-C Chart
Maternal Lipid Profile During Early Pregnancy
Pregnancy Outcomes in Familial Hypercholesterolemia
FELIC Study
FELIC Study
Early Fatty Streak & Lesions
Presence of native and oxidised LDL, monocytes
Lesion Sizes in Aortic Arch
Maternal Hypercholesterolemia and Treatment
Maternal V. Paternal FH Inheritance
Accelerated Subclinical Coronary Atherosclerosis
Atherosclerosis
Maternal Inheritance of FH
Standardized Mortality Ratio (SMR)
Inheritance pattern of FH
Endogenous Estrogens Lower Plasma PCSK9
Conclusions of Study
Estrogen & PCSK9 levels in Pregnancy
Estrogen & PCSK9 in Pregnancy
Treatment interventions and Premature cardiovascular disease
Treatment
Lipid Lowering Agents and Pregnancy Class
FH, Pregnancy & Apheresis
FH, Pregnancy & Apheresis
Use of Pregnancy Category D/X Meds
Statin Rx for Women of Child Bearing age
The Journal of Medicine Review
Take Home Points
Thank You
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