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The lipoprotein(a) [Lp(a)] field is rapidly evolving on many fronts, including understanding of the association between Lp(a) levels and cardiovascular disease (CVD) risk in different contexts, and how best to manage other CVD risk factors in patients with elevated Lp(a). Considering new insights into the clinical management of these patients, and in the absence of FDA-approved therapies to specifically lower Lp(a) levels, the question of in whom Lp(a) should be measured has become an increasingly important issue in clinical practice.
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- Olezarsen met the primary endpoint with a statistically significant reduction in triglyceride levels versus placebo
- First study to show an absolute reduction in acute pancreatitis in FCS patients, with olezarsen 80 mg monthly dose reducing events by 100 percent
- Olezarsen demonstrated a favorable safety and tolerability profile
- Ionis plans to file a New Drug Application with U.S. FDA in preparation for first potential independent launch
The United States Preventive Services Task Force (USPSTF) recently released its Final Recommendation Statement on Lipid Disorders in Children and Adolescents: Screening. NLA leadership disagrees with this release and communicated twice to USPSTF about the implications of this statement. The USPSTF has made no acknowledgment of the NLA’s concerns.