Update on Familial Hypercholesterolemia: An Expert Clinical Consensus from the National Lipid Association

The National Lipid Association has released an updated expert clinical consensus on the identification, diagnosis, and management of familial hypercholesterolemia (FH) available open access in the Journal of Clinical Lipidology. This updated expert consensus highlights advances in diagnosis, genetics, and treatment for this lifelong condition that requires lifelong attention.

Key updates in the new NLA guidance include:

• Reinforced recommendations for earlier and more systematic screening, including universal pediatric lipid screening and cascade screening of family members
• Clarification of clinical and genetic diagnostic approaches, emphasizing that genetic testing can complement — but is not required for — diagnosis
• Updated LDL-C treatment targets for both primary and secondary prevention, reflecting the high lifetime risk associated with FH
• Integration of newer lipid-lowering therapies, including PCSK9 inhibitors, bempedoic acid, and treatments specific to homozygous FH
• Expanded discussion of special populations, including children, pregnant individuals, and patients affected by health disparitie

Read the Full Consensus Statement   View the Press Release   Watch the CME Accredited Podcast    Listen to the CME Accredited Podcast