Fall 2013

Clinical Feature: An Update on Statin Safety with an Emphasis on Differences

Statin drugs have been studied in numerous controlled trials involving hundreds of thousands of study participants. Their use has resulted in reduced coronary artery disease (CAD) mortality, morbidity and, in several studies, all-cause mortality. Even though clinical trial evidence and clinical... more

Guest Editorial: Managing the Statin-Intolerant Patient: Low-Dose/Low-Frequency Treatment Regimens

A patient recently told me the story of her statin-intolerant sister, who was referred to a cardiologist she had seen for chest pain a few years earlier. When he entered the room, she explained that she could hardly walk or even get out of bed on atorvastatin. The doctor simply stated there was... more

EBM Tools for Practice: Evidence-Based Approach to the Use of CoQ10 to Deal with Statin Intolerance

Statins reportedly are the most effective of the lipid-modifying drugs in primary and secondary prevention of coronary heart disease.1-6 Yet, many patients are deprived of the benefits of statins because of their associated complications. The most common statin-related complication is myopathy,... more