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Potpourri 2016
The approach to understanding hypercholesterolemia, hypertriglyceridemia, or both, starts with consideration of the underlying lipoprotein abnormalities present.1,2 This is followed by asking to what degree genetic or acquired causes explain the observed abnormalities. Since those with lipoprotein... more
Evaluation of a patient’s risk for cardiovascular disease (CVD) is the basis of deciding whether to institute statin therapy. The 2013 ACC/AHA Guidelines on the Assessment of Cardiovascular Risk recommend using the Pooled Cohort Equation to predict the 10-year risk of having an atherosclerotic... more
Often there is a dichotomy regarding information published in the lay press versus what is presented in the medical literature. So it’s nice when both agree, except on those rare occasions, when both get it wrong. Despite numerous epidemiologic and observational studies to the contrary, Men’s... more
There is a large population >80 in the U.S., some who have either been advised to or chose to discontinue statin therapy. Randomized clinical trials have typically excluded very elderly subjects or group all elderly into age >65. There are vast differences in this population in terms of... more
Familial defective apolipoprotein B-100 (FDB) is an autosomal dominant disorder of lipid metabolism considered by international guidelines to be a genetically defined cause of familial hypercholesterolemia (FH).1–3 FDB arises from mutations in apolipoprotein B (apoB) affecting the affinity of apoB-... more
Perceptions of Fish Oil Dietary Supplements (FODS) According to 2008 national health statistics, fish oil dietary supplements (FODS) are the most commonly used supplements among U.S. adults.1 There is a general public perception that consumption of fish is a healthy dietary habit.2 This... more