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Spring 2013
Recent high-profile interventional studies and a large genetic association analysis have failed to show a benefit of raising high density lipoprotein cholesterol (HDL-C) levels on cardiovascular disease (CVD) outcomes, calling into question the validity of the HDL hypothesis. Among several... more
R.E. is a 58-year-old Asian male who finally quit smoking one month ago, and is now being treated for hypertension to goal with the combination amlodipine/benazepril. He has type 2 diabetes and takes metformin 500 mg bid. His initial lipid panel revealed a TC=230 mg/dL, LDL=140 mg/dL, HDL=35 mg/dL... more
Like many young clinicians starting out, Daniel Steinberg, MD, PhD, did not intend to build a career in Clinical Lipidology. But the Harvard-trained biochemist had motivation to pick a field quickly: it was 1950, the Korean War had just broken out, and he had served less than two years in World War... more
Lipoprotein(a), also referred to as Lp(a), is an unusual plasma lipoprotein that was first described by Berg in 1963.1 The lipoprotein(a) particle consists of a low density lipoprotein (LDL) particle to which a single molecule of apoprotein(a) is covalently bound via a disulfide linkage to... more